Biochemical JournalScientists at the Medical College of Georgia have identified a nutrient transporter cell, SLC5A8, that can be suppressed, causing cancer cells to die while not harming healthy cells.
This development, detailed in a study published in the Biochemical Journal, could have a profound impact on the future of cancer therapy, bringing a possible new target to the fore - a plasma membrane transporter. The suppression of the SLC4A8 denies important nourishment to tumorous cells which results in apoptosis, or cell death.
The biochemistry researchers experimented with breast cancer cells in mice to achieve positive results. Lead author, Dr. Vadivel Ganapathy, said of the studies, that they unravelled "a novel, hitherto unrecognized, mechanism for the tumour-suppressive role of a plasma membrane transporter independent of its transport function."
The implications of this research are important to the cancer research community and, in order to facilitate its dissemination, the Biochemical Journal will grant free access to journal article for two months from date of publication. (PDF)